SPOTting differences in peptide reactivity

Differences in reactivity of legume lipoxidases.

Presumptive evidence was recently reported for the existence of two types of lipoxidase enzymes (1). Differences in physical properties of lipoxidase preparations from soybeans (1) and other legumes (2) have been enumerated. Studies showing differences in reactivity of lipoxidases to activators and inhibitors would give further evidence to support their existence. Haining and Aslerod (3), using...

Individual Differences in Reactivity to Stress

Contribution of Peptide Backbone to Anti-Citrullinated Peptide Antibody Reactivity.

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, affecting approximately 1-2% of the world population. One of the characteristic features of RA is the presence of autoantibodies. Especially the highly specific anti-citrullinated peptide antibodies (ACPAs), which have been found in up to 70% of RA patients' sera, have received much attention. Several citrullinated protein...

Circadian differences in stress-induced pressor reactivity in mice.

The objective of this study was to determine the effect of chronic stress exposure on the circadian pattern of cardiovascular responses in mice. Using male C57BL6 mice with carotid arterial catheters, we tested the effect of 7 days of intermittent shaker stress on body weight, food intake, drinking activity, plasma corticosterone, mean arterial pressure (MAP), and heart rate. The stress was del...

Gender differences in age-related changes in HPA axis reactivity.

Possible differences between men and women in age-related patterns of hypothalamic-pituitary-adrenal (HPA) axis response to challenge were examined to test the hypothesis that women show greater age-related increase in HPA axis reactivity to challenge. Twenty-six younger subjects, 9 men and 17 women, ages 22-26 and 14 older subjects, 7 men and 7 women, ages 67-88 participated in the study. Patt...